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Ce and certain body fluids, such as serum, urine, sputum, cerebrospinal fluid and feces, where they are generally associated with a state of disease.237?40 S100A8/A9, S100A12 and S100B are even considered biomarkers of specific diseases, such as cancer, atherosclerosis and stroke.231,241?45 Like all alarmins previously described, S100 proteins lack a secretion leader sequence and therefore cannot

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