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Mary of major elements of cellular defense system that may operate against xenobiotic compounds in Oikopleura. A lipophilic xenobiotic (Xen) compound such as BaP entering the cell may activate xenobiotic receptors AhR or NRs. The activated receptors induce transcription of phase I, phase II and phase III biotransformation genes that metabolize the compound. Phase I biotransformation may create ROS

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