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O not seem consistent with its effects in mammals, possibly because PPARs or NR1C-like genes are absent in the Oikopleura genome. In vertebrates, PPARa ligands such as Clo induce many fatty acid beta oxidation and oxidative phosphorylation enzymes [44,45]. In contrast to vertebrates, Clo down-regulated several genes in energy metabolism pathways in Oikopleura. Our results in Oikopleura thus far do

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